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</html>";s:4:"text";s:2309:"<p>Cardiovascular safety of oral semaglutide in patients with type 2 diabetes: Rationale, design and patient baseline characteristics for the PIONEER 6 trial. Listing a study does not mean it has been evaluated by the U.S. Federal Government. </p> <p>PIONEER 1: Randomized Clinical Trial of the Efficacy and Safety of Oral Semaglutide Monotherapy in Comparison With Placebo in Patients With Type 2 Diabetes.  Safety of Semaglutide The safety profile of semaglutide was overall consistent with that of the GLP-1 receptor agonists (RA) class, with gastrointestinal adverse events being the most frequently reported adverse drug reactions with semaglutide. Oral semaglutide, the investigational first oral GLP-1 receptor agonist, could expand currently suboptimal treatment options for patients with type 2 diabetes and moderate renal impairment. However, semaglutide produced significantly greater weight loss than liraglutide, at an average of 4.4 versus 3.1 kg, and both were better than placebo, at 0.5 kg. Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes and Moderate Renal Impairment (PIONEER 5) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Both trials were presented this week at the 79th ADA Scientific Sessions in San Francisco, California, USA, with simultaneous publication in The Lancet Diabetes & Endocrinology. Aroda VR(1)(2), Rosenstock J(3), Terauchi Y(4), Altuntas Y(5), Lalic NM(6), Morales Villegas EC(7), Jeppesen OK(8), Christiansen E(8), Hertz CL(8), Haluzík M; PIONEER 1 Investigators. </p> <p>PIONEER 5 Investigators. Efficacy and safety of oral semaglutide in patients with type 2 diabetes and moderate renal impairment (PIONEER 5): a placebo-controlled, randomised, phase 3a trial. The mean pulse rate increased by 2 and 2.5 bpm with 0.5 and 1.0 mg dose of semaglutide in SUSTAIN 6, and by 4 bpm in PIONEER 6. Lancet Diabetes Endocrinol 2019; 7: 515 – 527 Read our disclaimer for details. PIONEER 5: Published medwireNews: The PIONEER 5 and 7 trials show the efficacy of oral semaglutide in people with moderate renal impairment and the potential for a flexible dosing regimen.. Related news story: PIONEER 2, PIONEER 4 show benefits of oral semaglutide in type 2 diabetes. </p>";s:7:"keyword";s:21:"pioneer 5 semaglutide";s:5:"links";s:8592:"<a href='https://boxwoodballs.com/docs/page.php?790614=target-nintendo-switch-console'>Target Nintendo Switch Console</a>,
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